The antimicrobial activity of the nanoparticles of silver stabilized by various natural and synthetic polymeric compounds concerning reference and clinical strains of Staphylococcus aureus is studied. It is established that the greatest effectiveness was displayed by the silver nanoparticles stabilized by polyvinyl alcohol, carboxymethylcellulose and poliazolidinammonium, the modified iodine hydrate ions. The low sensitivity of the studied strains to action of the nanoparticles stabilized by an oleate of S.