цефуроксим аксетил

Screen-printed Potentiometric Sensors for Cefuroxime Axetil Determination in Small Sample Volumes

Authors: Kulapina E. G., Kulapina O. I.

Potentiometric screen-printed cefuroxime axetil sensors were developed. The optimum membraneand carbon ink compositions were determined. The main sensor electroanalytical and operational characteristics were evaluated. The sensors were used to determination of cefuroxime axetil in small sample volumes of model water solutions and mixed saliva (oral fluid). Upgrading sensor designs opens up new sensor application for pharmaceutical kinetic antibiotic studies on the mixed saliva analysis and correction treatment of various pathological processes.

Solid-state Potentiometric Sensors for the Determination of Cefuroxime Axetil in Aqueous Media and Oral Fluid

Authors: Kulapina E. G., Kulapina O. I., Alieva I. К.

Cefuroxime axetil is a cephalosporin antibiotic of the second generation, it is used in the sequential therapy of patient with sinusitis, community-acquired pneumonia, and other infectious somatic pathologies. For the determination of cephalosporin antibiotics in different objects, spectroscopic, chromatographic, electrochemical methods, immunoassay, etc. are used, which demand for expen- sive devices and organic solvents. Potentiometric sensors let one expressively detect cefalosporin antibiotics in small samples without previous sample preparation.

Research of a State of Some the Cephalosporin Antibiotics in Water Environments by Spectrophotometry

Authors: Kulapina O. I., Karenko V. A., Kulapina E. G.

An express authenticity estimation of some cephalosporin antibiotics of II and III generations are developed by spectrophotometry. An identity of drugs such as cefotaxime (Russia) and claforan (France), cefuroxime (Russia) and cefuroxime axetil (England) is shown.

Determination of the Main Substances in the Preparations of Cephalexin and Cefuroxime Axetil

Authors: Kulapina E. G., Karenko V. A., Kulapina O. I.

Techniques of determination of the main substances in capsules of cephalexin and tablets of cefuroxime axetil have been elaborated. For separation of ancillary compounds, the two modes have been approbated, i.e. filtration and centrifugation. The advantage of the second means has been shown.

Ионометричесое определение цефуроксима и цефуроксим аксетила в биологических и лекарственных средах

Authors: Kulapina O. I., Михайлова М. С., Kulapina E. G.

Разработаны потенциометрические сенсоры на основе ионных ассоциатов цефуроксима с катионами тетраалкиламмония. Сенсоры обеспечивают широкий диапазон определяемых содержаний антибиотиков 1·10−4 (8·10−5) – 1·10−2 М; предел обнаружения антибиотиков составляет n·10−5 (10−6) М, что позволяет использовать сенсоры для определения цефуроксима и цефуроксим аксетила в биологических средах (ротовой жидкости) для корректировки и оптимизации курса лечения, а также для определения основного вещества в лекарственных препаратах.