ротовая жидкость

The influence of nature of active components and modifiers on electroanalytic properties of planar cefalexine-selective sensors

Authors: Kulapina E. G., Kulapina O. I., Ankina V. D.

The 1st generation cefalexine-cephalosporine antibiotic is used in the treatment of various infectious diseases. Spectrophotometry, kinetic spectrophotometry, spectrofluorimetry are proposed to determination of cefalexine in medicine and biological environment. Planar screenprinted sensors allow analyzing the micro-volumes of samples, which is important for the analysis of biological objects without preliminary samplepreparation. Depending on the active material and modifiers, you can create planar sensors for the determination of different organic compounds.

Modified Potentiometric Sensors of Various Types for Ceftriaxone Determination

Authors: Kulapina E. G., Chanina V. V.

The planar unmodified and modified by polyaniline, nanoparticles and their binary mixtures potentiometric sensors of various types were manufactured on the basis of tetradecylammonium associates (TDA) with complex connections silver (I) – ceftriaxone (Ag (I) – Ceftr). In sensors of I type electroactive components (EAC) and modifiers were brought in carboniferous ink. The polyvinylchloride plasticized unmodified and modified membranes on the basis [Ag2 (Ceftr)2] 2- · 2TDA were used in the sensors of II type; C (EAC) = 1,2,3%.

The Research of the Behavior of Cefixime in Aquatic and Biological Media by Spectrophotometric Method

Authors: Kulapina E. G., Kulapina O. I., Anikina V. D.

The research of behavior of cefixime in biological media was conducted by spectrophotometric method. It was shown that the maximum of light absorption of cefixime against the background of oral fluid is observed at λ = 292 nm and for blood serum at λ = 289 nm. The interval of linear dependence optical density – concentration of cefixime is 3–50 mkg/ml. The optimal conditions of precipitation of proteins in the studied biological media were revealed.

Solid-state Potentiometric Sensors for the Determination of Cefuroxime Axetil in Aqueous Media and Oral Fluid

Authors: Kulapina E. G., Kulapina O. I., Alieva I. К.

Cefuroxime axetil is a cephalosporin antibiotic of the second generation, it is used in the sequential therapy of patient with sinusitis, community-acquired pneumonia, and other infectious somatic pathologies. For the determination of cephalosporin antibiotics in different objects, spectroscopic, chromatographic, electrochemical methods, immunoassay, etc. are used, which demand for expen- sive devices and organic solvents. Potentiometric sensors let one expressively detect cefalosporin antibiotics in small samples without previous sample preparation.

СЕНСОРЫ ДЛЯ КОНТРОЛЯ СОДЕРЖАНИЯ ЦЕФИКСИМА В РОТОВОЙ ЖИДКОСТИ И СУСПЕНЗИИ «СУПРАКС»

Authors: Kulapina O. I., Макарова Н. М.

Разработаны новые потенциометрические сенсоры на основе органичес ких ионо-

обменников цефиксим – диметилдистеариламмоний, чувствительные к цефиксиму.

Определены их основные электроанали тические характеристики: интервал линей-

ности электродных функций сос тавляет 1·10−5 − 1·10−2 М, угловой коэффициент

28 ± 2, СЭАК = (3,11; 3,87%), время отклика 60–90 с; дрейф потенциала 2–4 мВ/сут;

срок службы 3 мес. Показана возможность применения сенсоров для ионометри-

Ионометричесое определение цефуроксима и цефуроксим аксетила в биологических и лекарственных средах

Authors: Kulapina O. I., Михайлова М. С., Kulapina E. G.

Разработаны потенциометрические сенсоры на основе ионных ассоциатов цефуроксима с катионами тетраалкиламмония. Сенсоры обеспечивают широкий диапазон определяемых содержаний антибиотиков 1·10⁻⁴(8·10⁻⁵) – 1·10⁻²М; предел обнаружения антибиотиков составляет n·10⁻⁵(10⁻⁶) М, что позволяет использовать сенсоры для определения цефуроксима и цефуроксим аксетила в биологических средах (ротовой жидкости) для корректировки и оптимизации курса лечения, а также для определения основного вещества в лекарственных препаратах.