This work is about the investigation of the interaction of porous silicon submicron particles with the HeLa cervical cancer cell line. Substrates of the porous silicon were obtained with the two-staged chemical method based on synthesis of silver nanoparticles from silver nitrate AgNO3 with the subsequent etching with fluoric acid HF in the presence of hydrogen peroxide H2O2 and mechanical separation of microparticles by shattering. The thickness of the obtained porous silicon layer measured by scanning electrom microscopy (SEM), was about 2 mkm.