Образец для цитирования:

Тучина Е. С. Некоторые аспекты антимикробного фотодинамического воздействия // Известия Саратовского университета. Новая серия. Серия: Химия. Биология. Экология. 2022. Т. 22, вып. 1. С. 33-46. DOI: https://doi.org/10.18500/1816-9775-2022-22-1-33-46

Статья опубликована на условиях лицензии Creative Commons Attribution 4.0 International (CC-BY 4.0).
Рубрика: 
Биология
УДК: 
577.344.3:579.61:666.1.056
Язык публикации: 
русский

Некоторые аспекты антимикробного фотодинамического воздействия

Авторы: 
Тучина Елена Святославна, СГУ. Биологический факультет. Кафедра биохимии и биофизики, 410012, Саратов, ул. Астраханская, 83, корп. 5, Биологический факультет, kliany@rambler.ru
Тип статьи для РИНЦ: 
RAR научная статья
Аннотация

Антимикробная фототерапия является альтернативным методом борьбы с клинически значимыми микроорганизмами, ассоциированными с поражениями кожи, слизистых оболочек ротовой полости, дыхательного, желудочно-кишечного и урогенитального трактов. Метод использует нетоксичные красители, называемые фотосенсибилизаторами, молекулы которых могут возбуждаться безвредным видимым светом с образованием активных форм кислорода. Многочисленные исследования метода in vitro и in vivo продемонстрировали уничтожение микроорганизмов или существенное сокращение их численности. Активные формы кислорода продуцируются при фотоактивации и атакуют такие мишени, как белки, липиды и нуклеиновые кислоты, присутствующие внутри микробных клеток. Обзор суммирует современные данные по антимикробному фотовоздействию.

Ключевые слова: 
фотодинамическая терапия, фотодинамическое воздействие, фотосенсибилизаторы, порфирины, УФИ, микроорганизмы
DOI: 
https://doi.org/10.18500/1816-9775-2022-22-1-33-46
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