Cite this article as:

Kulapina E. G., Dubasova A. Е., Kulapina O. I., Ankina V. D. “Electronic tongue” multi-systems for the separate determination of cefotaxime and cefazoline. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2021, vol. 21, iss. 1, pp. 4-11. DOI: https://doi.org/10.18500/1816-9775-2021-21-1-4-11

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Heading: 
Chemistry
UDC: 
543.615.33
Language: 
Russian

“Electronic tongue” multi-systems for the separate determination of cefotaxime and cefazoline

Authors: 
Kulapina Elena Grigorievna, Saratov State University , 83, Astrakhanskaya str., Saratov, 410012, Russia , kulapinaeg@mail.ru
Dubasova Anastasia Е., Saratov State University , 83, Astrakhanskaya str., Saratov, 410012, Russia , aedubasova@gmail.com
Kulapina Olga I., Saratov State Medical University named after V. I. Razumovsky. Department of Children's Diseases, 410012, Saratov, GSP Street Greater Cossack, 112, kulapinaoi@mail.ru, olgakulapina@mail.ru
Ankina Vlada D., Saratov State Medical University, 112, Bolshaya Kazachya Str., Saratov, 410010, Russia, vlada.ankina@mail.ru
Тип статьи для РИНЦ: 
RAR научная статья
Abstract

. Electroanalytical properties of unmodified and modified by polyaniline and by CuO nanoparticles solid-contact potentiometric sensors which are based on associates of tetradecylammonium with complex compounds of silver (I) with cephuroxime, cephotaxime and cephazoline Ag(β-lac)2TDA in solutions of corresponding antibiotics were studied. It was revealed that Ag(β-lac)2TDA –based sensors had no specificity to the basic ion but showed sensitivity to other cephalosporins. Taking into account the potentiometric selectivity coefficients and cross-sensitivity parameters of sensors based on different electrode-active components, their use for creating «electronic tongue» multi-sensor systems was shown. Arrays of low-selective potentiometric sensors were created for separate determination of cephazoline and cephotaxime in two-component model mixtures at concentration intervals of 2,5·10-4 – 0,01 М. The method of artificial neural networks was used for processing analytical signals (the relative error of determination not exceeding 13%). 

Key words: 
cephotaxime, cephazoline, potentiometric sensors, modifiers, multi-sensor systems
DOI: 
https://doi.org/10.18500/1816-9775-2021-21-1-4-11
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