Cite this article as:

Smirnova T. D., Zhelobitskaya E. A., Danilina T. G. Fluorimetric Determination of Pefloxacin in Pharmaceutical Preparation. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2016, vol. 16, iss. 4, pp. 372-376. DOI: https://doi.org/10.18500/1816-9775-2016-16-4-372-376

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Heading: 
Chemistry
UDC: 
544.522.121.2:546.661:615.33
Language: 
Russian

Fluorimetric Determination of Pefloxacin in Pharmaceutical Preparation

Authors: 
Smirnova Tatiana D., Saratov State University, 83, Astrakhanskaya St., Saratov, 410012, Russia, smirnovatd@mail.ru
Zhelobitskaya Elena Alexandrovna, SSU. Institute of Chemistry., 410012, Saratov, Astrakhanskaya str., 83, building. 1, Institute of Chemistry, SSU, smirnovatd@mail.ru
Danilina Tatiana Grigorievna, Saratov State University , 83, Astrakhanskaya str., Saratov, 410012, Russia , tanushechka900@mail.ru
Abstract

It is shown that pefloxacin forms a terbium complexes in neutral and mildly acidic conditions which are characterized by energy transfer. It is found that the micellar surfactant medium energy transfer efficiency increases. The maximum increase sensitized fluorescence intensity is observed in the presence of SDS micelles. A fluorimetric method for determination of pefloxacin in the drug was developed.

Key words: 
pefloxacin, luminescence, terbium, excitation energy transfer
DOI: 
https://doi.org/10.18500/1816-9775-2016-16-4-372-376
References

1. Du L. M., Wang J. P., Wang C. X. The fl uorescence characteristics of micelle inclusion of pefl oxacin and its application // Guang Pu Xue Yu Guang Pu Fen Xi. 2004. Vol. 24, № 7. P. 855–857.

2. Veiopoulou C., Ioannou P., Lianidou E. Application of terbium sensitized fl uorescence for the determination of fl uoroquinolone antibiotics pefl oxa cin, ciprofl oxacin and norfl oxacin in serum // J. of Pharm. and Biomed. Analysis. 2003. Vol. 15, № 12. P. 1839–1844.

3. Shtykov S. N. Surfactants in analysis : Progress and development trends // J. of Analyt. Chem. 2000. Vol. 55, № 7. P. 608–614.

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