Cite this article as:

Semyachkina-Glushkovskaya O. V., Ulanova M. V., Abdurashitov A. S., Gekalyuk A. S., Sindeeva O. A., Kassim M. . The Role of Beta-2-Adrenomediated Mechanisms of Injures of Venous Cerebral Blood Flow in Newborn Rats with Intracranial Hemorrhage. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2015, vol. 15, iss. 2, pp. 93-97. DOI: https://doi.org/10.18500/1816-9775-2015-15-2-93-97

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Heading: 
Biology
UDC: 
612. 146.2
Language: 
Russian

The Role of Beta-2-Adrenomediated Mechanisms of Injures of Venous Cerebral Blood Flow in Newborn Rats with Intracranial Hemorrhage

Authors: 
Semyachkina-Glushkovskaya Oksana V., Saratov State University , 83, Astrakhanskaya str., Saratov, 410012, Russia , glushkovskaya@mail.ru
Ulanova Maria V., SSU. Department of Biology., 410012, Saratov, Astrakhanskaya str., 83, building. 5, Faculty of Biology, maru-ulanova@mail.ru, glushkovskaya@mail.ru
Abdurashitov Arkadiy S., Saratov State University , 83, Astrakhanskaya str., Saratov, 410012, Russia , abdurashitov-optics@mail.ru, aarkady@icloud.com
Gekalyuk A. S., SSU. Department of Biology., 410012, Saratov, Astrakhanskaya str., 83, building. 5, Faculty of Biology, glushkovskaya@mail.ru
Sindeeva O. A., Saratov State University , 83, Astrakhanskaya str., Saratov, 410012, Russia , mouse-oa@rambler.ru
Kassim M., Saratov State University , 83, Astrakhanskaya str., Saratov, 410012, Russia , glushkovskaya@mail.ru
Abstract

Development of stress-induced hemorrhagic cerebral infarction in neonatal rats is accompanied by pathological relaxation of cerebral veins that provokes the appearance of venous insufficiency and reduced outflow of blood from the brain. These critical changes in cerebral blood flowprecede intracranial hemorrhage and may be predictors of the risk of stroke in the first days after birth. The high sensitivity of the beta-2-adrenergic receptors to their pharmacologi- cal stimulation inthe pre-stroke group indicates that adreno-related vasorelaxation mechanisms play an important role in the disorder of venous blood flow and open the prospect for further study of pharmacological correction of these processes and prevention of hemorrhagic cerebral infarct in infants.

Key words: 
cerebral blood flow, intracranial hemorrhage, beta- 2-adrenorelated vasorelaxation
DOI: 
https://doi.org/10.18500/1816-9775-2015-15-2-93-97
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