бензимидазолохиназолины

Comparison of Cytotoxic Activity of Compounds from the Benzimidazolequinazoline and Pyridopyrimidine Series

Authors: Ivonin M. A., Fomin A. S., Burygin G. L., Sorokin V. V.

Colorimetrically using the MTT assay the cytotoxic activity of 5-aryl-1,2,3,4,5,6-hexahydrobenz[4,5]imidazolo[1,2-a]quinazolines and a tautomeric mixture of 4-amino-2-phenyl-6H-pyrido[1,2-a] pyrimidin-3-carbonitrile with 2-(phenyl(pyridin-2-ylamino)methyl)- malononitrile was screened. These compounds were obtained by the three-component condensation of aromatic aldehydes (benzaldehyde, 3-bromobenzaldehyde, 4-methoxybenzaldehyde), heterocyclic amines (2-aminobenzimidazole or 2-aminopyridine) and cyclohexanone or malonic acid dinitrile in comparison with the starting amines.

Synthesis and Ways of Formation of Hydroxyphenyl Substituted Benz[4,5]imidazole-1,2,3,4,5,6- hexahydro[1,2-a]quinazolines

Authors: Ivonin M. A., Krivenko A. P., Abdulhamid H. A., Krivenko A. P., Ivonin M. A., Sorokin V. V.

To synthesize new potentially biologically active benzimidazoloquinazolines, a three-component condensation of 2-aminobenzimidazole, cyclohexanone and hydroxylatedbenzaldehydes was studied. The reaction proceeds regioselectively when the equimolar ratios of the reagents are boiled for 3 hours in N,N-dimethylformamide and is accompanied by the formation of ortho-phenyl substituted hexahydrobenz[4,5]imidazolo [1,2-a]quinazolines having an angular articulation of the rings and a different number and position of hydroxyl groups in the phenyl substituent.

Synthesis of Opto-R-Phenyl Benzimidazoloheksahydroquinazoline with Angular Articulation Rings

Authors: Ivonin M. A., Dymolazova D. K., Sorokin V. V., Krivenko A. P.

Condensation of 2-aminobenzimidazole, ortho-substituted benzaldehydes and cyclohexanone proceeds with the formation of 10-o-Rsubstituted phenyl benz[4,5]imidazolo-6,7,8,9,10,11-hexahydro[1,2-a] quinazolines having angular articulation rings, strukture which is set using IR, NMR, 1 H, 13C spectra.