We developed various options of biologically active agents based on the core–shell structure technology. They were obtained by layering biocompatible polymer on the surface of the carriers. As a core, we used a heterocyclic compound comprising of enamine and flavonoid nanoaggregates. As a shell, we used polу azolidinе аmmonium modified by iodine hydrate-ions. Our results implied a significant increase in antimicrobial activity of the preparations developed by us.